Professional Appointments and Affiliations
Assistant Professor of Chemistry
Louis Martarano Career Development Professor
220 Chemistry Building
University Park, PA 16802
104 Chemistry Building
Ph.D., Chemistry, Massachusetts Institute of Technology, 2012
A.B., Chemistry, Princeton University, 2006
Honors and Awards
Charles E. Kaufman Foundation New Investigator Award (2018-2020)
Jane Coffin Childs Memorial Fund Postdoctoral Fellowship (2013-2016)
National Defense Science and Engineering Graduate Fellowship (2008-2011)
The Cotruvo lab uses biochemistry and chemical biology to understand metal selectivity in biological systems. We study how bacteria selectively acquire and utilize lanthanides and apply what we learn to design biotechnologies for rare earth detection, capture, and separations. We also study roles of transition metals in infectious and neurodegenerative disease.
Cotruvo, J.A., Jr. The chemistry of lanthanides in biology: Recent discoveries, emerging principles, and technological applications. ACS Cent. Sci. 2019, doi: 10.1021/acscentsci.9b00642.
Ho, J.V. and Cotruvo, J.A., Jr. A periplasmic binding protein for pyrroloquinoline quinone. Biochemistry 2019, 58, 2665-2669.
Featherston, E.R., Rose, H.R., McBride, M.J., E.M. Taylor, Boal, A.K., and Cotruvo, J.A., Jr. Biochemical and structural characterization of XoxG and XoxJ and their roles in lanthanide-dependent methanol dehydrogenase activity. ChemBioChem 2019, doi: 10.1002/cbic.201900184.
Mattocks, J.A., Ho, J.V., and Cotruvo, J.A., Jr. A selective, protein-based fluorescent sensor with picomolar affinity for rare earth elements. J. Am. Chem. Soc. 2019, 141, 2857-2861.
Cook, E.C., Featherston, E.R., Showalter, S.A., and Cotruvo, J.A., Jr. Structural basis for rare earth element recognition by Methylobacterium extorquens lanmodulin. Biochemistry 2019, 58, 120-125.
Cotruvo, J.A., Jr., Featherston, E.R., Mattocks, J.A., Ho, J.V., and Laremore, T.N. Lanmodulin: A highly selective lanthanide-binding protein from a lanthanide-utilizing bacterium. J. Am. Chem. Soc. 2018, 140, 15056-15061.
Prior to Penn State:
Krishnamoorthy, L.,* Cotruvo, J.A., Jr.,* Chan, J., Kaluarachchi, H., Muchenditsi, A., Pendyala, V.S., Jia, S., Aron, A.T., Ackerman, C.M., Vander Wal, M.N., Guan, T., Smaga, L.P., Farhi, S.S., New, E.J., Lutsenko, S., and Chang, C.J. Copper regulates cyclic-AMP-dependent lipolysis. Nat. Chem. Biol., 2016, 12, 586-592. (*Co-first authors)
Cotruvo, J.A., Jr., Stich, T.A., Britt, R.D., and Stubbe, J. Mechanism of assembly of the dimanganese-tyrosyl radical cofactor of class Ib ribonucleotide reductase: Enzymatic generation of superoxide is required for tyrosine oxidation via a MnIIIMnIV intermediate. J. Am. Chem. Soc. 2013, 135, 4027-4039.
Boal, A.K., Cotruvo, J.A., Jr., Stubbe, J., and Rosenzweig, A.C. Structural basis for activation of class Ib ribonucleotide reductase. Science 2010, 329, 1526-1530.
Cotruvo, J.A., Jr. and Stubbe, J. An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase. Biochemistry 2010, 49, 1297-1309.