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Amie
Boal
Associate Professor of Chemistry and of Biochemistry and of Molecular Biology
Boal

Boal

Professional Appointments and Affiliations

Associate Professor of Chemistry

Associate Professor of Biochemistry and Molecular Biology

Office 

326 Chemistry Building
University Park, PA 16802

Education

Ph.D. Chemistry, California Institute of Technology, 2008

B.A. Chemistry, Pomona College, 2002

Honors and Awards

Camille Dreyfus Teacher-Scholar Award, 2018

NIH Pathway to Independence Award, 2012

NIH Ruth L. Kirschstein NRSA Postdoctoral Fellowship, 2011-2012

American Cancer Society Postdoctoral Fellowship, 2010-2011

Selected Publications

 

Blaesi, E.J.*; Palowitch, G.M.*; Hu, K.*; Kim, A.J.; Rose, H.R.; Alapati, R.B.; Lougee, M.G.; Kee, H.J.; Taguchi, A.T.; Tan, K.O.; Griffin, R.G.; Krebs, C.; Matthews, M.L.; Silakov, A.; Bollinger, J.M., Jr.; Allen, B.D.; Boal, A.K. “Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical.” Proc. Natl. Acad. Sci. USA 2018. In press.

 

Rose, H.R.*; Ghosh, M.K.*; Maggiolo, A.O.; Pollock, C.J.; Blaesi, E.J.; Hajj, V.; Wei, Y.; Rajakovich, L.J.; Chang, W.-c.; Han, Y.; Hajj, M.; Pandelia, M.-E.; Krebs, C.; Bollinger, J.M., Jr.; Boal, A.K. “Structural basis for superoxide activation of Flavobacterium johnsoniae class I ribonucleotide reductase and for radical initiation by its dimanganese cofactor.” Biochemistry 2018, 57, 2679-2693.

 

Mitchell, A.J.*; Dunham, N.P.*; Martinie, R.J.; Bergman, J.A.; Pollock, C.J.; Hu, K.; Allen, B.D.; Chang, W.-c.; Silakov, A.; Bollinger, J.M., Jr.; Krebs, C.; Boal, A.K. “Visualizing the reaction cycle in an iron(II) and 2-(oxo)-glutarate-dependent hydroxlase.” J. Am. Chem. Soc. 2017, 139, 13830-13836.

 

Mitchell, A.J.; Dunham, N.P.; Bergman, J.A.; Wang, B.; Chang, W.-c. Liu, X.; Boal, A.K. “Structure-guided engineering of a small-molecule aliphatic halogenase.” Biochemistry 2017, 56, 441-444.

 

Mitchell, A.J.; Zhu, Q.; Maggiolo, A.O.; Ananth, N.; Hillwig, M.L.; Liu, X.; Boal, A.K. “Structural basis for selective chlorination by iron- and 2-oxo-glutarate-dependent WelO5.” Nat. Chem. Biol. 2016, 12, 636-640.

 

Schwalm, E.L.*; Grove, T.L.*; Booker, S.J.; Boal, A.K. “Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.” Science 2016, 352, 309-312.

 

Boal, A. K., Grove, T. L., McLaughlin, M. I., Yennawar, N. H., Booker, S. J., and Rosenzweig, A. C. Structural basis for methyl transfer by a radical SAM enzyme. Science, 2011, 332, 1089-1092.

 

Boal, A. K., Cotruvo, J. A., Jr., Stubbe, J., and Rosenzweig, A. C. Structural basis for activation of class Ib ribonucleotide reductase. Science, 2010, 329, 1526-1530.

 

Boal, A. K., and Rosenzweig, A. C. Crystal structures of cisplatin bound to a human copper chaperone. J. Am. Chem. Soc., 2009, 131, 14196-14197.

 

Boal, A. K., Genereux, J. C., Sontz, P. A., Gralnick, J. A., Newman, D. K., and Barton, J. K. Redox signaling between DNA repair proteins for efficient lesion detection. Proc. Natl. Acad. Sci. USA, 2009, 106, 15237-15242.